Posters

Dynamic Feeding Enables Increased Total Protein Yield in Industrial Fed-Batch Bioprocesses

Authors: Johannes Wirth, Stefan Wieschalka, Anja Schäfer, Lorenzo Bisgen and Jadranka Koehn
Mai 2019 (1 MB)

TurboCellTM – A Fast Way to Stable Production Cell Lines

Authors: Britta Reichenbächer, Brigitte Anic, Katharina Köther, Janet Köhler, Jadranka Koehn
May 2019 (1 MB)

Reduced Clone Variation of CHO Cells by Single Targeted Integration

Authors: Katharina Koether, Carmen Butscher, Sebastian Wiese, Jadranka Koehn
May 2019 (1 MB)

Generation of Recombinant CHO TurboCell™ Lines - for the Production of PASylated Human DNase I

Authors: Serge M. Stamm, Michaela Gebauer, Roland Wagner, Arne Skerra
May 2019 (1 MB)

Intensification Of A Platform Fedbatch Process - A CDMO Perspective

Authors: Marvin Kadisch, Isabelle Dumrese, Kurt Russ
May 2019 (1 MB)

Dynamic Biomass-based Feeding of an Industrial CHO Fed-batch Process

Authors: Stefan Wieschalka, Johannes Wirth, Anja Schäfer, Franziska Nohr, Lorenzo Bisgen, Jadranka Koehn
May 2019 (1 MB)

Advanced Formulations of Biopharmaceuticals

Authors: Jadranka Koehn, Jens Altrichter, Birgit Schwab, Konstantin Petropoulos, Sabine Hauck
November 2018 (3 MB)

Intensification of mAb downstream processes using modular innovative purification technologies

Authors: Anja Trapp, Verena Kössler, Gregor Neumann, Sven Schubert, Alexander Faude
November 2018 (1 MB)

Scale-up of an affinity chromatography to 1000 L manufacturing scale using space-time optimized resin and yield (STORY) approach

Authors: Marlene Holder, Sabrina Graser, Hannah Ness, Markus Blender, Thomas Ziglasch, Anja Trapp, Alexander Faude, Thilo Grob
October 2018 (2 MB)

Impurity Precipitation for mAb Capture Optimization

Authors: Silke Bastian, Coralie Tanzer, Anja Trapp, Jadranka Koehn
September 2018 (1 MB)

TurboCellTM Line Development 10 Weeks from DNA to Top4 Clone Decision

Authors: Britta Reichenbächer, Brigitte Anic, Stefanie Oeding, Jadranka Koehn
September 2018 (1 MB)

Virus Clearance by Salt Tolerant Anion Exchange Chromatography in Flow Through Mode

Authors: Verena Vollmar, Sabine Faust, Anja Trapp, Egbert Müller, Benjamin Zeitler, Alexander Faude
September (1 MB)

Generation of Recombinant CHO TurboCell Lines for the Production of PASylated Human DNase I

Authors: Serge M. Stamm, Michaela Gebauer, Roland Wagner, Arne Skerra
September (1 MB)

Take Full Advantage of Caprylic Acid Induced Impurity Precipitation in MAb Purification

Authors: Anja Trapp, Natalie Hörold, Sabine Faust, Alexander Faude
September 2018 (1 MB)

Controlled Integration Site Mapping by NGS-Based - Targeted Locus Amplification and Regular PCR

Authors: Katharina Koether, Isabel Proneth, Janet Köhler, Jadranka Koehn
September 2018 (1MB)

Advanced Formulations of Biopharmaceuticals

Authors: Martin Scholz(1), Stefan R. Schmidt(2), Birgit Schwab(2), Roland Derwand(1), Sabine Hauck(1)
(1) Leukocare, (2) Rentschler Biopharma
March 2018 (2 MB)

High-Density Cell Banking for Intensified Seed Trains

Authors: Marvin Kadisch, Lisa Weißer, Kurt Russ
March 2018 (3 MB)

Taking Advantage of the Virus Inactivating Effect in Caprylic Acid-Based Impurity Precipitation for Downstream Processes

Authors: Sabine Faust, Natalie Hörold, Sven Schubert, Anja Trapp, Alexander Faude
May 2017 (2 MB)

Single-Use or Multi-Use – How Proper Does It Work in Small-Scale?

Authors: Stefan Wieschalka, Janine Seidemann, Anja Schäfer, Stefan R. Schmidt
May 2017 (4 MB)

Analysis of Product Quality Attributes by MIR Spectroscopy

Author: Anne Steinkämper, Ralf Masuch, Kurt Russ
May 2017 (2 MB)

Manufacturing of Complex Biobetters: Half-Life Extended Fusion Proteins and Bispecific Molecules

Author: Stefan R. Schmidt
January 2017 (3 MB)

Leveraging HT Product Quality Analysis using Semi-preparative Protein A-HPLC

Authors: Anja Gerster, Alexander Faude und Dethardt Müller
April 2016 (4 MB)

Molecular Properties of Antibodies and their Derivatives Impacting Manufacturing

Author: Stefan R. Schmidt
March 2016 (4 MB)

FcγRIII (CD16) and GD2 Binding Assay for an IgG using Surface Plasmon Resonance (SPR; Biacore) as a Surrogate for Evaluation of Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)

Authors: Marco Bareth, Stefan Stranner, Manfred Schuster, Melanie Krist, Andreas Maier, Philipp Goerttler, Anton Walser
September 2015 (4 MB)

Increased Antibody Yield due to Modification of LC and HC Expression by Gene Regulatory Elements

Authors: Claas Wodarczyk, Britta Reichenbächer, Andreas Schulze, Janet Köhler, Anja Gerster, Bernd Rehberger, Dethardt Müller
June 2015 (1 MB)

Virus Removal by Simple Depth Filtration in a Two-Step Downstream Process for mAb Production

Authors: Alexander Faude, Mario Metzger, Anja Gerster, Marcus Peiker, Sabine Faust, Sybille Ebert, Sophie Winterfeld, Nicole Mang, Dethardt Müller
July 2014 (1 MB)

Setting up transfection-based recombinant AAV production in the iCELLisTM single use fi xed-bed bioreactor

Authors: Antje Pegel, Jessica Wegele, Marion Kunz, Claudia Küppers, Andreas Schulze, Antje Rößner, Daniel Kreß, Florian Sonntag, Markus Hörer
October 2013 (3 MB)

Novel tools could give stable producer cell lines their break for commercial manufacturing of recombinant AAV vectors

Authors: Verena Emmerling, Karlheinz Holzmann, Karin Lanz, Jessica Wegele, Stefan Kochanek, Markus Hörer
October 2013 (3 MB)

Accelerating stable recombinant cell line development by targeted integration

Authors: Bernd Rehberger, Claas Wodarczyk, Britta Reichenbächer, Janet Köhler, Renée Weber, Dethardt Müller
June 2013 (3 MB)

Novel approaches to render stable producer cell lines viable for the commercial manufacturing of RAAV-based gene therapy vectors

Authors: Verena Emmerling, Karlheinz Holzmann, Karin Lanz, Stefan Kochanek, Markus Hörer
June 2013 (3 MB)

Fast track API manufacturing from shake flask to production scale using a 1,000 L single use facility

Authors: Benjamin Minow, Sven Reiser, Peter Rogge
March 2013 (2 MB)