5th Laupheim Biotech Days


With the topic "Bioprocess Intensification" the 5th Biotech Days will spotlight all aspects of the intensification of cell culture-based bioprocesses in the biopharmaceutical industry.

The conference will include both up- and downstream processing and will sport a scientific bandwidth ranging from molecular switches to loop-controlled hybrid processes and intelligent purification strategies.

This turns the 5th Biotech Days into an ideal stage for a rich diversity of strategies to modify process-specific key attributes, enabling a significant enhancement of productivity, product quality, reliability and consistency as well as product safety.

Topics are:

  • Cells for the production of biologics
  • Vectors for cells
  • Omics-technology for cells and processes
  • Minimal-invasive control methods
  • Fast protein purification strategies
  • Product stability


September 20, 2018
16:00 Reception & Exhibition
17:30 Keynote
19:30 Dinner

September 21, 2018
08:00 Exhibition
08:45 Welcome
09:00 Presentations
16:30 Final remarks and farewell "Get-Together"


Schloss Großlaupheim
88471 Laupheim




Leonardo Royal Hotel Ulm
Mörikestraße 17
89077 Ulm 
Code: "5th Biotech Days"

A shuttle bus will run between the hotel and the conference venue.
Please find our shuttle bus schedule here






16:00 Registration & exhibition open
Kulturhaus Schloss Großlaupheim
16:00 Networking & reception
Kulturhaus Schloss Großlaupheim
17:15 Welcome
Dr. Ralf Otto
17:30 Keynote speaker & keyplayer award
Michael Scholl
18:00 Exhibition, networking & reception
Kulturhaus Schloss Großlaupheim
19:30 Dinner
Kulturhaus Schloss Großlaupheim
08:00 Registration & Exhibition Open


08:45 Welcome
Prof. Dr. Roland Wagner

Cell line biology and genetics
09:00 Domesticating CHO cells for protein manufacture - the convoluted story of genes, chromosomes, and population genetics in bioreactors
Prof. Dr. Florian Wurm
09:30 Genome scale science for CHO: towards better understanding and control of phenotype in cell lines and subclones
Prof. Dr. Nicole Borth
10:00 Coffee break, poster session & exhibition
Bioprocess technology upstream
11:00 Perfusion process at high cell density for the production of biopharmaceuticals
Dr. Véronique Chotteau
11:30 A rational strategy for the reduction of protein aggregation in mammalian cell cultures
Prof. Dr. Friedemann Hesse
12:00 Cell culture-based viral vaccines: process intensification and monitoring
Prof. Dr. Udo Reichl
12:30 Lunch break, poster session & exhibition
Downstream processing
14:00 Continuous downstream processing of biopharmaceuticals
Prof. Dr. Alois Jungbauer
14:30 Process analytical technology – where analytics meets modeling
Prof. Dr. Jürgen Hubbuch
15:00 Coffee break & exhibition
15:30 Process intensification strategies in the context of disposables
Dr. Stefan R. Schmidt
16:00 Intensified monoclonal antibody purification using impurity precipitation strategies
Anja Trapp
16:30 Final remarks and farewell “Get-Together”

Media Partner

Platin Sponsors

Gold Sponsors

Silver Sponsors

Young Scientists Cell Culture Biotechnology Retreat

The Young Scientists Cell Culture Biotechnology Retreat on September 20, 2018 at Rentschler Biopharma will kick-off the 5th Laupheim Biotech Days.


08:00 Registration
08:45 Welcome
Prof. Dr. Roland Wagner
09:00 The BEST of both worlds – targeted integration and multiple copies: How can this go together for improved cell line development
Emanuel Kreidl
09:30 Towards microfluidic single-cell cultivation of mammalian cell lines
Julian Schmitz
10:00 Compartmented 13C metabolic flux analysis and metabolomics reveal CHO’s mitochondrial shuttle activities under various cultivation conditions
Andy Wiranata Wijaya
10:30 Coffee break & poster
11:00 Cell culture-based perfusion processes for flavivirus production
Alexander Nikolay
11:30 Development of M³C strategies in production processes with CHO cell cultures to prevent the formation of product aggregation during process
Alina Handl
12:00 Membrane-based separation of aqueous two-phase systems for the purification of monoclonal antibodies
Thomas Kruse
12:30 Lunch & poster
14:45 Facility tour

In the context of the 5th Biotech Days and the Young Scientists Cell Culture Biotechnology Retreat we would like to take photos again in order to publish them on online media (Internet, Intranet, Infoscreen, social media (Facebook, LinkedIn, Xing), in-house newspaper) later. Of course you do not have to be photographed. In this case, simply tell or let the photographer know that you do not want to be photographed. Otherwise, we assume your consent. But even in this case, if you have changed your mind, you can always object to the use of the photo(s) for the above-mentioned purposes - simply send an e-mail to communications@rentschler-biopharma.com and we will no longer use the photo in future.